Shogo Moriyama, Miyu Mae, Daiki Shibata, Hiroyuki Yamakoshi, Shinji Kajimoto, Takakazu Nakabayashi, Takayoshi Ishimoto, Kaiki Mogi, Hironao Sajiki, Shuji Akai, Yoshinari Sawama (2023) Multiple deuteration of triphenylphosphine and live-cell Raman imaging of deuterium-incorporated Mito-Q., Chemical communications (Cambridge, England)
Published in 2023 Sep 18 (Electronic publication in Sept. 18, 2023, midnight )
(Abstract) All aromatic C-H bonds of triphenylphosphine (PPh(3)) were efficiently replaced by C-D bonds using Ru/C and Ir/C co-catalysts in 2-PrOH and D(2)O, an inexpensive deuterium source. Furthermore, non-radioactive and safe deuterium-incorporated Mito-Q (drug candidate) was prepared from deuterated PPh(3) and used for the live-cell Raman imaging to evaluate the mitochondrial uptake.